PP2Acα-B′/PR61 Holoenzyme of Toxoplasma gondii Is Required for the Amylopectin Metabolism and Proliferation of Tachyzoites

PP2Acα-B′/PR61 Holoenzyme of Toxoplasma gondii Is Required for the Amylopectin Metabolism and Proliferation of Tachyzoites

ABSTRACT Here, we report that the inhibition of the PP2A subfamily by okadaic acid results in an accumulation of polysaccharides in the acute infection stage (tachyzoites) of Toxoplasma gondii, which is a protozoan of global zoonotic importance and a model for the apicomplexan parasites. The loss of...

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Bibliographic Details
Main Authors: Mingxiu Zhao, Yi Yang, Yue Shi, Xueqiu Chen, Yimin Yang, Lingtao Pan, Zhendong Du, Hongchao Sun, Chaoqun Yao, Guangxu Ma, Aifang Du
Format: Article
Language:English
Published: American Society for Microbiology 2023-06-01
Series:Microbiology Spectrum
Subjects:
Toxoplasma gondii
PP2Acα
B′/PR61 subunit
amylopectin metabolism
virulence
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00104-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.00104-23

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