Inhibition of anti-tumor immunity by melanoma cell-derived Activin-A depends on STING

Inhibition of anti-tumor immunity by melanoma cell-derived Activin-A depends on STING

The transforming growth factor-β (TGF-β) family member activin A (hereafter Activin-A) is overexpressed in many cancer types, often correlating with cancer-associated cachexia and poor prognosis. Activin-A secretion by melanoma cells indirectly impedes CD8+ T cell-mediated anti-tumor immunity and pr...

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Bibliographic Details
Main Authors: Katarina Pinjusic, Giovanna Ambrosini, Joao Lourenco, Nadine Fournier, Christian Iseli, Nicolas Guex, Olga Egorova, Sina Nassiri, Daniel B. Constam
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Immunology
Subjects:
cancer
intercellular communication
scRNA-seq
profiling
knockdown
activin
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1335207/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1335207/full

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