An Unusual Two-Domain Thyropin from Tick Saliva: NMR Solution Structure and Highly Selective Inhibition of Cysteine Cathepsins Modulated by Glycosaminoglycans

An Unusual Two-Domain Thyropin from Tick Saliva: NMR Solution Structure and Highly Selective Inhibition of Cysteine Cathepsins Modulated by Glycosaminoglycans

The structure and biochemical properties of protease inhibitors from the thyropin family are poorly understood in parasites and pathogens. Here, we introduce a novel family member, Ir-thyropin (IrThy), which is secreted in the saliva of <i>Ixodes ricinus</i> ticks, vectors of Lyme borrel...

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Bibliographic Details
Main Authors: Zuzana Matoušková, Katarína Orsághová, Pavel Srb, Jana Pytelková, Zdeněk Kukačka, Michal Buša, Ondřej Hajdušek, Radek Šíma, Milan Fábry, Petr Novák, Martin Horn, Petr Kopáček, Michael Mareš
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
cathepsin
cysteine protease
tick
parasite
saliva
thyropin
Online Access:https://www.mdpi.com/1422-0067/25/4/2240

Internet

https://www.mdpi.com/1422-0067/25/4/2240

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