Identification of (Z)-2-benzylidene-dihydroimidazothiazolone derivatives as tyrosinase inhibitors: Anti-melanogenic effects and in silico studies

Identification of (Z)-2-benzylidene-dihydroimidazothiazolone derivatives as tyrosinase inhibitors: Anti-melanogenic effects and in silico studies

As part of our continuous search for novel tyrosinase inhibitors, we designed 5,6-dihydroimindazo[2,1-b]thiazol-3(2H)-one (DHIT) derivatives based on the structure of MHY773; a potent tyrosinase inhibitor with a 2-iminothiazolidin-4-one template. Of the 11 DHIT derivatives synthesized using a Knoeve...

Full description

Bibliographic Details
Main Authors: Heejeong Choi, Il Young Ryu, Inkyu Choi, Sultan Ullah, Hee Jin Jung, Yujin Park, YeJi Hwang, Yeongmu Jeong, Sojeong Hong, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
(Z)-2-Benzylidene-dihydroimidazothiazolone
Docking simulation
Kojic acid
Tyrosinase inhibitor
Anti-melanogenesis
DHIT template
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022000447

Internet

http://www.sciencedirect.com/science/article/pii/S2001037022000447

Similar Items