Lipopolysaccharide-induced podocyte injury is regulated by calcineurin/NFAT and TLR4/MyD88/NF-κB signaling pathways through angiopoietin-like protein 4

Lipopolysaccharide-induced podocyte injury is regulated by calcineurin/NFAT and TLR4/MyD88/NF-κB signaling pathways through angiopoietin-like protein 4

Podocyte injury is an important cause of proteinuria. Angiopoietin-like protein 4 (Angptl4) is a secreted glycoprotein and has a role in proteinuria. However, the exact role of Angptl4 in podocyte injury and its upstream regulators has not been clarified. In this study, we used lipopolysaccharide (L...

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Bibliographic Details
Main Authors: Xiujin Shen, Chunhua Weng, Yucheng Wang, Cuili Wang, Shi Feng, Xiayu Li, Heng Li, Hong Jiang, Haibing Wang, Jianghua Chen
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-03-01
Series:Genes and Diseases
Subjects:
Angiopoietin-like protein 4
Calcineurin/NFAT
LPS
Podocyte injury
TLR4/MyD88/NF-κB
Online Access:http://www.sciencedirect.com/science/article/pii/S235230422030088X

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http://www.sciencedirect.com/science/article/pii/S235230422030088X

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