Aryl Hydrocarbon Receptor (AhR)-Mediated Signaling in iPSC-Derived Human Motor Neurons

Aryl Hydrocarbon Receptor (AhR)-Mediated Signaling in iPSC-Derived Human Motor Neurons

Exposure to environmental pollutants and endogenous metabolites that induce aryl hydrocarbon receptor (AhR) expression has been suggested to affect cognitive development and, particularly in boys, also motor function. As current knowledge is based on epidemiological and animal studies, in vitro mode...

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Bibliographic Details
Main Authors: Saima Jalil Imran, Barbora Vagaska, Jan Kriska, Miroslava Anderova, Mario Bortolozzi, Gino Gerosa, Patrizia Ferretti, Radim Vrzal
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Pharmaceuticals
Subjects:
hiPSCs
AhR
motor neurons
CYP1A1
CYP1B1
L-Kyn
Online Access:https://www.mdpi.com/1424-8247/15/7/828

Internet

https://www.mdpi.com/1424-8247/15/7/828

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