CCP5 and CCP6 retain CP110 and negatively regulate ciliogenesis

CCP5 and CCP6 retain CP110 and negatively regulate ciliogenesis

Abstract Background The axonemal microtubules of primary cilium undergo a conserved protein posttranslational modification (PTM) — polyglutamylation. This reversible procedure is processed by tubulin tyrosine ligase-like polyglutamylases to form secondary polyglutamate side chains, which are metabol...

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Bibliographic Details
Main Authors: Yujuan Wang, Yuan Zhang, Xinyu Guo, Yiqiang Zheng, Xinjie Zhang, Shanshan Feng, Hui-Yuan Wu
Format: Article
Language:English
Published: BMC 2023-05-01
Series:BMC Biology
Subjects:
CCP5
CCP6
Polyglutamylation
Ciliogenesis
CP110
Online Access:https://doi.org/10.1186/s12915-023-01622-1

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