Mouse models of SMA show divergent patterns of neuronal vulnerability and resilience

Mouse models of SMA show divergent patterns of neuronal vulnerability and resilience

Abstract Background Spinal muscular atrophy (SMA) is a form of motor neuron disease affecting primarily children characterised by the loss of lower motor neurons (MNs). Breakdown of the neuromuscular junctions (NMJs) is an early pathological event in SMA. However, not all motor neurons are equally v...

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Bibliographic Details
Main Authors: Victoria Woschitz, Irene Mei, Eva Hedlund, Lyndsay M. Murray
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Skeletal Muscle
Subjects:
Spinal muscular atrophy
Mouse model
Selective vulnerability
Neuromuscular junction
NMJ
Motor neuron
Online Access:https://doi.org/10.1186/s13395-022-00305-9

Internet

https://doi.org/10.1186/s13395-022-00305-9

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