E3 ubiquitin ligase MAGI3 degrades c-Myc and acts as a predictor for chemotherapy response in colorectal cancer

E3 ubiquitin ligase MAGI3 degrades c-Myc and acts as a predictor for chemotherapy response in colorectal cancer

Abstract Background Recurrence and chemoresistance constitute the leading cause of death in colorectal cancer (CRC). Thus, it is of great significance to clarify the underlying mechanisms and identify predictors for tailoring adjuvant chemotherapy to improve the outcome of CRC. Methods By screening...

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Hauptverfasser: Haibo Wang, Wenjing Yang, Qiong Qin, Xiaomei Yang, Ying Yang, Hua Liu, Wenxiu Lu, Siyu Gu, Xuedi Cao, Duiping Feng, Zhongtao Zhang, Junqi He
Format: Artikel
Sprache:English
Veröffentlicht: BMC 2022-07-01
Schriftenreihe:Molecular Cancer
Schlagworte:
MAGI3
c-Myc
Colorectal cancer
PDZ
Recurrence
Fluoropyrimidine-based systemic chemotherapy
Online Zugang:https://doi.org/10.1186/s12943-022-01622-9

Online

https://doi.org/10.1186/s12943-022-01622-9

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