Characterization and chemoproteomic profiling of protein O-GlcNAcylation in SOD1-G93A mouse model

Characterization and chemoproteomic profiling of protein O-GlcNAcylation in SOD1-G93A mouse model

Abstract Background Amyotrophic lateral sclerosis (ALS) is a devastating motor neuron disease. Protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification has been found to affect the processing of several important proteins implicated in ALS. However, the overall level and cellular localization...

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Bibliographic Details
Main Authors: Yi Hao, Zhongzhong Li, Xinyan Du, Qingsong Xie, Dongxiao Li, Shaoyuan Lei, Yansu Guo
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Molecular Medicine
Subjects:
O-linked β-N-acetylglucosamine (O-GlcNAc)
Chemoproteomics
Amyotrophic lateral sclerosis (ALS)
SOD1-G93A mice
Chemoenzymatic labeling
Click chemistry
Online Access:https://doi.org/10.1186/s10020-025-01134-4

Internet

https://doi.org/10.1186/s10020-025-01134-4

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