Thiamine for the Treatment of Cardiac Arrest–Induced Neurological Injury: A Randomized, Blinded, Placebo‐Controlled Experimental Study

Thiamine for the Treatment of Cardiac Arrest–Induced Neurological Injury: A Randomized, Blinded, Placebo‐Controlled Experimental Study

Background Thiamine supplementation has demonstrated protective effects in a mouse model of cardiac arrest. The aim of this study was to investigate the neuroprotective effects of thiamine in a clinically relevant large animal cardiac arrest model. The hypothesis was that thiamine reduces neurologic...

Full description

Bibliographic Details
Main Authors: Lauge Vammen, Cecilie Munch Johannsen, Cecilie Dahl Baltsen, Casper Nørholt, Mark Eggertsen, Signe Mortensen, Lasse Vormfenne, Amalie Povlsen, Michael W. Donnino, Bo Løfgren, Lars W. Andersen, Asger Granfeldt
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
acute myocardial infarction
animal experiment
heart arrest
neurological injury
thiamine
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.122.028558

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.122.028558

Similar Items