Accounting for population stratification in practice: a comparison of the main strategies dedicated to genome-wide association studies.

Genome-Wide Association Studies are powerful tools to detect genetic variants associated with diseases. Their results have, however, been questioned, in part because of the bias induced by population stratification. This is a consequence of systematic differences in allele frequencies due to the dif...

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Bibliographic Details
Main Authors: Matthieu Bouaziz, Christophe Ambroise, Mickael Guedj
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3244428?pdf=render