MIIP inhibits the growth of prostate cancer via interaction with PP1α and negative modulation of AKT signaling

MIIP inhibits the growth of prostate cancer via interaction with PP1α and negative modulation of AKT signaling

Abstract Background Over-activation of phosphatidylinositol 3-kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) signaling pathway is one of important mechanisms to promote castration resistant prostate cancer, the final stage of prostate cancer (PCa). Dysregulation of PP1-meditaed AKT dephospho...

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Bibliographic Details
Main Authors: Guang Yan, Yi Ru, Fengqi Yan, Xin Xiong, Wei Hu, Tao Pan, Jianming Sun, Chi Zhang, Qinhao Wang, Xia Li
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Cell Communication and Signaling
Subjects:
MIIP
Proliferation
Prostate cancer
PP1α
PI3K-AKT-mTOR
Online Access:http://link.springer.com/article/10.1186/s12964-019-0355-1

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http://link.springer.com/article/10.1186/s12964-019-0355-1

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