CD4+ and CD8+ regulatory T cell characterization in the rat using a unique transgenic Foxp3-EGFP model

CD4+ and CD8+ regulatory T cell characterization in the rat using a unique transgenic Foxp3-EGFP model

Abstract Background Regulatory T cells (Treg) in diverse species include CD4+ and CD8+ T cells. In all species, CD8+ Treg have been only partially characterized and there is no rat model in which CD4+ and CD8+ FOXP3+ Treg are genetically tagged. Results We generated a Foxp3-EGFP rat transgenic line...

Full description

Bibliographic Details
Main Authors: Séverine Ménoret, Laurent Tesson, Séverine Remy, Victor Gourain, Céline Sérazin, Claire Usal, Aude Guiffes, Vanessa Chenouard, Laure-Hélène Ouisse, Malika Gantier, Jean-Marie Heslan, Cynthia Fourgeux, Jeremie Poschmann, Carole Guillonneau, Ignacio Anegon
Format: Article
Language:English
Published: BMC 2023-01-01
Series:BMC Biology
Subjects:
Immune tolerance
Genome editing
Gene knockin
Foxp3
CD4+ Treg
CD8+ Treg
Online Access:https://doi.org/10.1186/s12915-022-01502-0

Internet

https://doi.org/10.1186/s12915-022-01502-0

Similar Items