CD4+ and CD8+ regulatory T cell characterization in the rat using a unique transgenic Foxp3-EGFP model

CD4+ and CD8+ regulatory T cell characterization in the rat using a unique transgenic Foxp3-EGFP model

Abstract Background Regulatory T cells (Treg) in diverse species include CD4+ and CD8+ T cells. In all species, CD8+ Treg have been only partially characterized and there is no rat model in which CD4+ and CD8+ FOXP3+ Treg are genetically tagged. Results We generated a Foxp3-EGFP rat transgenic line...

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Bibliographic Details
Main Authors:	Séverine Ménoret, Laurent Tesson, Séverine Remy, Victor Gourain, Céline Sérazin, Claire Usal, Aude Guiffes, Vanessa Chenouard, Laure-Hélène Ouisse, Malika Gantier, Jean-Marie Heslan, Cynthia Fourgeux, Jeremie Poschmann, Carole Guillonneau, Ignacio Anegon
Format:	Article
Language:	English
Published:	BMC 2023-01-01
Series:	BMC Biology
Subjects:	Immune tolerance Genome editing Gene knockin Foxp3 CD4+ Treg CD8+ Treg
Online Access:	https://doi.org/10.1186/s12915-022-01502-0

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