Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer

Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer

Utilizing molecular data to derive functional physiological models tailored for specific cancer cells can facilitate the use of individually tailored therapies. To this end we present an approach termed PRIME for generating cell-specific genome-scale metabolic models (GSMMs) based on molecular and p...

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Bibliographic Details
Main Authors: Keren Yizhak, Edoardo Gaude, Sylvia Le Dévédec, Yedael Y Waldman, Gideon Y Stein, Bob van de Water, Christian Frezza, Eytan Ruppin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-11-01
Series:eLife
Subjects:
genome-scale metabolic modeling
cancer
selective drug target
personalized medicine
Online Access:https://elifesciences.org/articles/03641

Internet

https://elifesciences.org/articles/03641

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