Partial p53 reactivation is sufficient to induce cancer regression

Partial p53 reactivation is sufficient to induce cancer regression

Abstract Background Impaired p53 function is one of the central molecular features of a tumor cell and even a partial reduction in p53 activity can increase the cancer risk in mice and men. From a therapeutic perspective it is noteworthy that tumor cells often become addicted to the absence of p53 p...

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Bibliographic Details
Main Authors: Boris Klimovich, Laura Meyer, Nastasja Merle, Michelle Neumann, Alexander M. König, Nikolaos Ananikidis, Corinna U. Keber, Sabrina Elmshäuser, Oleg Timofeev, Thorsten Stiewe
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
p53
Tumor suppressor gene
p53 reactivation
Molecular therapy
Leukemia
Lymphoma
Online Access:https://doi.org/10.1186/s13046-022-02269-6

Internet

https://doi.org/10.1186/s13046-022-02269-6

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