Loss of thymic function promotes EAE relapse in anti-CD52-treated mice

Loss of thymic function promotes EAE relapse in anti-CD52-treated mice

Anti-CD52 treatment creates a long-lasting CD4 T cell lymphopenia and reduces multiple sclerosis (MS) relapses in humans. In contrast, anti-CD52 therapy at disease onset more fully suppresses experimental autoimmune encephalomyelitis (EAE) in mice, and T cell repopulation is rapid. To test whether p...

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Bibliographic Details
Main Authors: Adeolu O. Adegoke, Jiaxin Lin, Colin C. Anderson
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Current Research in Immunology
Subjects:
Thymectomy
Recent thymic emigrants
Multiple sclerosis
EAE
Alemtuzumab
Anti-CD52
Online Access:http://www.sciencedirect.com/science/article/pii/S2590255522000026

Internet

http://www.sciencedirect.com/science/article/pii/S2590255522000026

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