The primate EAE model points at EBV-infected B cells as a preferential therapy target in multiple sclerosis

The primate EAE model points at EBV-infected B cells as a preferential therapy target in multiple sclerosis

The remarkable clinical efficacy of anti-CD20 monoclonal antibodies (mAb) in relapsing-remitting multiple sclerosis (RRMS) points at the critical involvement of B cells in the disease. However, the exact pathogenic contribution of B cells is poorly understood. In this publication we review new data...

Full description

Bibliographic Details
Main Authors: Bert A 'T Hart, Sunil Anwar Jagessar, Krista eHaanstra, Ernst eVerschoor, Jon eLaman, Yolanda eKap
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-06-01
Series:Frontiers in Immunology
Subjects:
Immunotherapy
B cell
EAE
ebv
T cell
MS
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00145/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00145/full

Similar Items