Effects of tofacitinib therapy on arginine and methionine metabolites in association with vascular pathophysiology in rheumatoid arthritis: A metabolomic approach

Effects of tofacitinib therapy on arginine and methionine metabolites in association with vascular pathophysiology in rheumatoid arthritis: A metabolomic approach

IntroductionRheumatoid arthritis (RA) has been associated with changes in lipid, arginine and NO metabolism with increased cardiovascular (CV) risk. The aim of this study is to evaluate the effect of tofacitinib, a Janus kinase (JAK) inhibitor, on arginine and methionine metabolism in correlation wi...

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Bibliographic Details
Main Authors: Boglárka Soós, Attila Hamar, Anita Pusztai, Monika Czókolyová, Edit Végh, Szilvia Szamosi, Zsófia Pethő, Katalin Gulyás, György Kerekes, Sándor Szántó, Gabriella Szűcs, Uwe Christians, Jelena Klawitter, Tamás Seres, Zoltán Szekanecz
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Medicine
Subjects:
rheumatoid arthritis
tofacitinib
atherosclerosis
metabolomics
arginine
methionine
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.1011734/full

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https://www.frontiersin.org/articles/10.3389/fmed.2022.1011734/full

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