BARD1 mystery: tumor suppressors are cancer susceptibility genes

BARD1 mystery: tumor suppressors are cancer susceptibility genes

Abstract The full-length BRCA1-associated RING domain 1 (BARD1) gene encodes a 777-aa protein. BARD1 displays a dual role in cancer development and progression as it acts as a tumor suppressor and an oncogene. Structurally, BARD1 has homologous domains to BRCA1 that aid their heterodimer interaction...

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Bibliographic Details
Main Authors: Yousef M. Hawsawi, Anwar Shams, Abdulrahman Theyab, Wed A. Abdali, Nahed A. Hussien, Hanan E. Alatwi, Othman R. Alzahrani, Atif Abdulwahab A. Oyouni, Ahmad O. Babalghith, Mousa Alreshidi
Format: Article
Language:English
Published: BMC 2022-06-01
Series:BMC Cancer
Subjects:
BARD1
Breast Cancer
Tumor suppressor
Oncogene
Online Access:https://doi.org/10.1186/s12885-022-09567-4

Internet

https://doi.org/10.1186/s12885-022-09567-4

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