Cardiac LXRα protects against pathological cardiac hypertrophy and dysfunction by enhancing glucose uptake and utilization

Cardiac LXRα protects against pathological cardiac hypertrophy and dysfunction by enhancing glucose uptake and utilization

Abstract Pathological cardiac hypertrophy is characterized by a shift in metabolic substrate utilization from fatty acids to glucose, but the molecular events underlying the metabolic remodeling remain poorly understood. Here, we investigated the role of liver X receptors (LXRs), which are key regul...

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Bibliographic Details
Main Authors: Megan V Cannon, Herman HW Silljé, Jürgen WA Sijbesma, Inge Vreeswijk‐Baudoin, Jolita Ciapaite, Bart van der Sluis, Jan van Deursen, Gustavo JJ Silva, Leon J de Windt, Jan‐Åke Gustafsson, Pim van der Harst, Wiek H van Gilst, Rudolf A de Boer
Format: Article
Language:English
Published: Springer Nature 2015-07-01
Series:EMBO Molecular Medicine
Subjects:
glucose metabolism
left ventricular hypertrophy
liver X receptor
nuclear receptor
O‐GlcNAcylation
Online Access:https://doi.org/10.15252/emmm.201404669

Internet

https://doi.org/10.15252/emmm.201404669

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