miR-19b-3p promotes colon cancer proliferation and oxaliplatin-based chemoresistance by targeting SMAD4: validation by bioinformatics and experimental analyses

miR-19b-3p promotes colon cancer proliferation and oxaliplatin-based chemoresistance by targeting SMAD4: validation by bioinformatics and experimental analyses

Abstract Background As a disease with extremely complex molecular mechanisms, many deregulated miRNAs have been identified in colon cancer. Few studies have been performed by using Ingenuity Pathways Analysis (IPA) to predict miRNAs specifically expressed in colon cancer. Methods A characteristic mi...

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Bibliographic Details
Main Authors: Tao Jiang, Ling Ye, Zhongbo Han, Yuan Liu, Yinxue Yang, Zhihai Peng, Junwei Fan
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
miR-19b-3p
SMAD4
Proliferation
Oxaliplatin
Chemoresistance
Online Access:http://link.springer.com/article/10.1186/s13046-017-0602-5

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http://link.springer.com/article/10.1186/s13046-017-0602-5

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