Fingolimod (FTY720) stimulates Ca(2+)/calcineurin signaling in fission yeast.

Fingolimod (FTY720) stimulates Ca(2+)/calcineurin signaling in fission yeast.

Fingolimod hydrochloride (FTY720) is the first in class of sphingosine 1-phosphate (S1P) receptor modulator approved to treat multiple sclerosis via down-regulation of G protein-coupled S1P receptor 1 by its phosphorylated form (FTY720-P). Many studies have revealed that FTY720 exerts various biolog...

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Bibliographic Details
Main Authors: Kanako Hagihara, Ayako Kita, Aya Mizukura, Mariko Yao, Yuki Kitai, Tatsuki Kunoh, Takashi Masuko, Sumio Matzno, Kenji Chiba, Reiko Sugiura
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3849299?pdf=render

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http://europepmc.org/articles/PMC3849299?pdf=render

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