Positive reinforcement mediated by midbrain dopamine neurons requires D1 and D2 receptor activation in the nucleus accumbens.

The neural basis of positive reinforcement is often studied in the laboratory using intracranial self-stimulation (ICSS), a simple behavioral model in which subjects perform an action in order to obtain exogenous stimulation of a specific brain area. Recently we showed that activation of ventral teg...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Elizabeth E Steinberg, Josiah R Boivin, Benjamin T Saunders, Ilana B Witten, Karl Deisseroth, Patricia H Janak
Format: Artikel
Sprache:English
Veröffentlicht: Public Library of Science (PLoS) 2014-01-01
Schriftenreihe:PLoS ONE
Online Zugang:http://europepmc.org/articles/PMC3986242?pdf=render