Knockdown circTRIM28 enhances tamoxifen sensitivity via the miR-409-3p/HMGA2 axis in breast cancer

Knockdown circTRIM28 enhances tamoxifen sensitivity via the miR-409-3p/HMGA2 axis in breast cancer

Highlights 1. The expression of circTRIM28 was upregulated in BC. 2. Silencing circTRIM28 enhanced tamoxifen sensitivity and cell apoptosis, whereas curbed cell proliferation, cell migration and invasion in BC cells. 3. CircTRIM28 expedited BC by targeting miR-409-3p. 4. MiR-409-3p repressed BC by r...

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Bibliographic Details
Main Authors: Shiyong Yang, Changwu Zou, Yuxin Li, Xianguo Yang, Wei Liu, Guannan Zhang, Nina Lu
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Reproductive Biology and Endocrinology
Subjects:
Breast cancer
circTRIM28
miR-409-3p
HMGA2
Tamoxifen
Online Access:https://doi.org/10.1186/s12958-022-01011-3

Internet

https://doi.org/10.1186/s12958-022-01011-3

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