Transcriptomic Analysis of Insulin-Secreting Murine Hepatocytes Transduced with an Integrating Adeno-Associated Viral Vector

Transcriptomic Analysis of Insulin-Secreting Murine Hepatocytes Transduced with an Integrating Adeno-Associated Viral Vector

Type 1 Diabetes (T1D) is a chronic metabolic disorder for which current treatments are unable to prevent the onset of complications. Previously, we used an adeno-associated viral vector (AAV8) to deliver furin-cleavable human insulin (INS-FUR) to the livers of diabetic non-obese diabetic (NOD) mice...

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Bibliographic Details
Main Authors: Alexandra L. G. Mahoney, Sergio Joshua, Najah T. Nassif, Ann M. Simpson
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:International Journal of Translational Medicine
Subjects:
type 1 diabetes
adeno-associated viral (AAV) vector
piggyBac transposon vector
RNA-Seq
differential gene expression
pancreatic transdifferentiation
Online Access:https://www.mdpi.com/2673-8937/3/3/26

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https://www.mdpi.com/2673-8937/3/3/26

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