Theoretical Assessment of the Ligand/Metal/Quadruplex Recognition in the Non-Canonical Nucleic Acids Structures

Quadruplexes (GQs), peculiar DNA/RNA motifs concentrated in specific genomic regions, play a vital role in biological processes including telomere stability and, hence, represent promising targets for anticancer therapy. GQs are formed by folding guanine-rich sequences into square planar G-tetrads w...

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Автори: Nikoleta Kircheva, Stefan Dobrev, Vladislava Petkova, Snezhana Bakalova, Jose Kaneti, Silvia Angelova
Формат: Стаття
Мова:English
Опубліковано: MDPI AG 2023-08-01
Серія:Molecules
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Онлайн доступ:https://www.mdpi.com/1420-3049/28/16/6109