Histone Deacetylases and Histone Deacetylase Inhibitors in Neuroblastoma

Histone Deacetylases and Histone Deacetylase Inhibitors in Neuroblastoma

Histone deacetylases (HDACs) are enzymes that play a key role in regulating gene expression by remodeling chromatin structure. An imbalance of histone acetylation caused by deregulated HDAC expression and activity is known to promote tumor progression in a number of tumor types, including neuroblast...

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Bibliographic Details
Main Authors: Monica Phimmachanh, Jeremy Z. R. Han, Yolande E. I. O’Donnell, Sharissa L. Latham, David R. Croucher
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
neuroblastoma
histone deacetylases
histone deacetylase inhibitor
acetylation
differentiation
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.578770/full

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https://www.frontiersin.org/article/10.3389/fcell.2020.578770/full

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