Evidence of polygenic regulation of the physiological presence of neurofilament light chain in human serum

Evidence of polygenic regulation of the physiological presence of neurofilament light chain in human serum

IntroductionThe measurement of neurofilament light chain (NfL) in blood is a promising biomarker of neurological injury and disease. We investigated the genetic factors that underlie serum NfL levels (sNfL) of individuals without neurological conditions.MethodsWe performed a discovery genome-wide as...

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Bibliographic Details
Main Authors: Marisol Herrera-Rivero, Edith Hofer, Aleksandra Maceski, David Leppert, Pascal Benkert, Jens Kuhle, Reinhold Schmidt, Michael Khalil, Heinz Wiendl, Monika Stoll, Klaus Berger
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Neurology
Subjects:
GWAS
neurofilament light chain
serum biomarkers
neuropathology
genetics
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2023.1145737/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2023.1145737/full

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