Plasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M

Abstract Plasmodium falciparum causes the most severe malaria in humans. Immunoglobulin M (IgM) serves as the first line of humoral defense against infection and potently activates the complement pathway to facilitate P. falciparum clearance. A number of P. falciparum proteins bind IgM, leading to i...

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Bibliographic Details
Main Authors: Chenggong Ji, Hao Shen, Chen Su, Yaxin Li, Shihua Chen, Thomas H. Sharp, Junyu Xiao
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-38320-z