Pan-Phosphodiesterase Inhibitors Attenuate TGF-β-Induced Pro-Fibrotic Phenotype in Alveolar Epithelial Type II Cells by Downregulating Smad-2 Phosphorylation

Pan-Phosphodiesterase Inhibitors Attenuate TGF-β-Induced Pro-Fibrotic Phenotype in Alveolar Epithelial Type II Cells by Downregulating Smad-2 Phosphorylation

Airway remodeling is a pathological process that accompanies many chronic lung diseases. One of the important players in this process are epithelial cells, which under the influence of pro-inflammatory and pro-fibrotic factors present in the airway niche, actively participate in the remodeling proce...

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Bibliographic Details
Main Authors: Katarzyna Wójcik-Pszczoła, Grażyna Chłoń-Rzepa, Agnieszka Jankowska, Bruno Ferreira, Paulina Koczurkiewicz-Adamczyk, Elżbieta Pękala, Elżbieta Wyska, Krzysztof Pociecha, Reinoud Gosens
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Pharmaceuticals
Subjects:
phosphodiesterase inhibitors
alveolar epithelial type II cells
transforming growth factor type β
asthma
lung fibrosis
airway remodeling
Online Access:https://www.mdpi.com/1424-8247/15/4/423

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https://www.mdpi.com/1424-8247/15/4/423

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