ACLY is the novel signaling target of PIP2/PIP3 and Lyn in acute myeloid leukemia

ACLY is the novel signaling target of PIP2/PIP3 and Lyn in acute myeloid leukemia

A fundamental feature of tumor progression is reprogramming of metabolic pathways. ATP citrate lyase (ACLY) is a key metabolic enzyme that catalyzes the generation of Acetyl-CoA and is upregulated in cancer cells and required for their growth. The phosphoinositide 3-kinase (PI3K) and Src-family kina...

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Bibliographic Details
Main Authors: Johnvesly Basappa, Mevlut Citir, Qian Zhang, Hong Y. Wang, Xiaobin Liu, Olga Melnikov, Hafiz Yahya, Frank Stein, Rainer Muller, Alexis Traynor-Kaplan, Carsten Schultz, Mariusz A. Wasik, Andrzej Ptasznik
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Heliyon
Subjects:
Biological sciences
Biochemistry
Cancer research
Health sciences
Metabolism
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844020307556

Internet

http://www.sciencedirect.com/science/article/pii/S2405844020307556

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