APOBEC3G Regulation of the Evolutionary Race Between Adaptive Immunity and Viral Immune Escape Is Deeply Imprinted in the HIV Genome

APOBEC3G Regulation of the Evolutionary Race Between Adaptive Immunity and Viral Immune Escape Is Deeply Imprinted in the HIV Genome

APOBEC3G (A3G) is a host enzyme that mutates the genomes of retroviruses like HIV. Since A3G is expressed pre-infection, it has classically been considered an agent of innate immunity. We and others previously showed that the impact of A3G-induced mutations on the HIV genome extends to adaptive immu...

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Bibliographic Details
Main Authors: Faezeh Borzooee, Krista D. Joris, Michael D. Grant, Mani Larijani
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
CTL epitope
APOBEC3G (A3G)
HIV
immune escape
viral evolution
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03032/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.03032/full

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