Rho kinase inhibitors ameliorate cognitive impairment in a male mouse model of methamphetamine-induced schizophrenia

Rho kinase inhibitors ameliorate cognitive impairment in a male mouse model of methamphetamine-induced schizophrenia

Schizophrenia (SCZ) is a severe psychiatric disorder characterized by positive symptoms, negative symptoms, and cognitive deficits. Current antipsychotic treatment in SCZ improves positive symptoms but has major side effects and little impact on negative symptoms and cognitive impairment. The pathoe...

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Bibliographic Details
Main Authors: Jingzhu Liao, Geyao Dong, Wenjun Zhu, Bolati Wulaer, Hiroyuki Mizoguchi, Masahito Sawahata, Yue Liu, Kozo Kaibuchi, Norio Ozaki, Toshitaka Nabeshima, Taku Nagai, Kiyofumi Yamada
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Pharmacological Research
Subjects:
Rho kinase
Visual discrimination
Methamphetamine
Cognition
Phospho-MYPT1
Phospho-MLC2
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661823001949

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http://www.sciencedirect.com/science/article/pii/S1043661823001949

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