Persulfidation of transcription factor FOXO1 at cysteine 457: A novel mechanism by which H2S inhibits vascular smooth muscle cell proliferation

Persulfidation of transcription factor FOXO1 at cysteine 457: A novel mechanism by which H2S inhibits vascular smooth muscle cell proliferation

Introduction: The proliferation of vascular smooth muscle cells (VSMCs) is an important physiological and pathological basis for many cardiovascular diseases. Endogenous hydrogen sulfide (H2S), the third gasotransmitter, is found to preserve vascular structure by inhibiting VSMC proliferation. Howev...

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Bibliographic Details
Main Authors: Xiaoyu Tian, Dan Zhou, Yong Zhang, Yunjia Song, Qingyou Zhang, Dingfang Bu, Yan Sun, Liling Wu, Yuan Long, Chaoshu Tang, Junbao Du, Yaqian Huang, Hongfang Jin
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Journal of Advanced Research
Subjects:
FOXO1
Persulfidation
Hydrogen sulfide
Vascular smooth muscle cell
Proliferation
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123220301326

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http://www.sciencedirect.com/science/article/pii/S2090123220301326

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