Vγ2 x PD-L1, a Bispecific Antibody Targeting Both the Vγ2 TCR and PD-L1, Improves the Anti-Tumor Response of Vγ2Vδ2 T Cell

Vγ2 x PD-L1, a Bispecific Antibody Targeting Both the Vγ2 TCR and PD-L1, Improves the Anti-Tumor Response of Vγ2Vδ2 T Cell

The potent cytotoxic property of Vγ2Vδ2 T cells makes them attractive for adoptive T cell transfer therapy. The transfusing of the expanded Vγ2Vδ2 T cells into cancer patients shows well-tolerated, but the clinical response rates are required to be improved, implying that there is still an unmet eff...

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Bibliographic Details
Main Authors: Rui Yang, Qing He, Hui Zhou, Cheng Gong, Xing Wang, Xingpan Song, Fang Luo, Yang Lei, Qian Ni, Zili Wang, Shasha Xu, Yan Xue, Man Zhang, Haimei Wen, Lijuan Fang, Liang Zeng, Yongxiang Yan, Jian Shi, Jing Zhang, Jizu Yi, Pengfei Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
[Vγ2 x PD-L1]
Vγ2Vδ2 T cell
PD-L1
adoptive transfer
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.923969/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.923969/full

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