PRIMA-1 inhibits Y220C p53 amyloid aggregation and synergizes with cisplatin in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide. Although many therapeutic options are available, several factors, including the presence of p53 mutations, impact tumor development and therapeutic resistance. TP53 is the second most frequently mutated gen...

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Bibliographic Details
Main Authors: Mariana M. Paz, Giulia D. S. Ferretti, Mafalda M. C. Martins-Dinis, Beatriz I. S. Ferreira, Amanda Faier-Pereira, Thibaut Barnoud, Otacilio C. Moreira, Jerson L. Silva, Yraima Cordeiro, Luciana P. Rangel
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Molecular Biosciences
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1165132/full