Tetrahydrobiopterin Supplementation Improves Endothelial Function But Does Not Alter Aortic Stiffness in Patients With Rheumatoid Arthritis

BackgroundRheumatoid arthritis is a systemic inflammatory condition associated with increased cardiovascular risk that may be due to underlying endothelial dysfunction and subsequent aortic stiffening. We hypothesized that supplementation with tetrahydrobiopterin (BH4) would recouple endothelial nit...

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Bibliographic Details
Main Authors: Kaisa M. Mäki‐Petäjä, Lisa Day, Joseph Cheriyan, Frances C. Hall, Andrew J. K. Östör, Nicholas Shenker, Ian B. Wilkinson
Format: Article
Language:English
Published: Wiley 2016-02-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.115.002762