Bisbenzimide compounds inhibit the replication of prototype and pandemic potential poxviruses

Bisbenzimide compounds inhibit the replication of prototype and pandemic potential poxviruses

ABSTRACTWe previously identified the bisbenzimide Hoechst 33342 (H42) as a potent multi-stage inhibitor of the prototypic poxvirus, the vaccinia virus (VACV), and several parapoxviruses. A recent report showed that novel bisbenzimide compounds similar in structure to H42 could prevent human cytomega...

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Bibliographic Details
Main Authors: Jerzy Samolej, Diogo Correa Mendonca, Nicole Upfold, Marion McElwee, Mariann Landsberger, Artur Yakimovich, Arvind H. Patel, Blair L. Strang, Jason Mercer
Format: Article
Language:English
Published: American Society for Microbiology 2024-04-01
Series:Microbiology Spectrum
Subjects:
vaccinia virus
antiviral
DNA replication
viral transcription
mpox
Online Access:https://journals.asm.org/doi/10.1128/spectrum.04072-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.04072-23

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