Synergistic influence of cytokine gene polymorphisms over the risk of dementia: A multifactor dimensionality reduction analysis
ObjectiveEvidence supports the important role of neuroinflammation in some types of dementia. This study aimed to evaluate the effect of epistasis of gene cytokines such as interleukin (IL)-α, IL-6, tumor necrosis factor (TNFα), and interferon-gamma (IFN-γ) on the susceptibility to the development o...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.952173/full |
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| author | Teresa Juárez-Cedillo Nancy Martínez-Rodríguez Gilberto Vargas-Alarcon Enrique Juárez-Cedillo Antonio Valle-Medina Osvaldo Garrido-Acosta Alfredo Ramirez |
| author_facet | Teresa Juárez-Cedillo Nancy Martínez-Rodríguez Gilberto Vargas-Alarcon Enrique Juárez-Cedillo Antonio Valle-Medina Osvaldo Garrido-Acosta Alfredo Ramirez |
| author_sort | Teresa Juárez-Cedillo |
| collection | DOAJ |
| description | ObjectiveEvidence supports the important role of neuroinflammation in some types of dementia. This study aimed to evaluate the effect of epistasis of gene cytokines such as interleukin (IL)-α, IL-6, tumor necrosis factor (TNFα), and interferon-gamma (IFN-γ) on the susceptibility to the development of dementia.Materials and methodsIn the study, 221 patients diagnosed with dementia and 710 controls were included. The multifactor-dimensionality reduction (MDR) analysis was performed to identify the epistasis between SNP located in genes of IL-α (rs1800587), IL-6 (rs1800796), TNFα (rs361525 and rs1800629), and IFNγ (rs2069705). The best risk prediction model was identified based on precision and cross-validation consistency.ResultsMultifactor-dimensionality reduction analysis detected a significant model with the genes TNFα, IFNγ, IL1α, and IL6 (prediction success: 72%, p < 0.0001). When risk factors were analyzed with these polymorphisms, the model achieved a similar prediction for dementia as the genes-only model.ConclusionThese data indicate that gene–gene interactions form significant models to identify populations susceptible to dementia. |
| first_indexed | 2024-04-12T11:43:04Z |
| format | Article |
| id | doaj.art-a63cc33d025e47bdaa2763cefe98b228 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-12T11:43:04Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-a63cc33d025e47bdaa2763cefe98b2282022-12-22T03:34:32ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-10-011410.3389/fnagi.2022.952173952173Synergistic influence of cytokine gene polymorphisms over the risk of dementia: A multifactor dimensionality reduction analysisTeresa Juárez-Cedillo0Nancy Martínez-Rodríguez1Gilberto Vargas-Alarcon2Enrique Juárez-Cedillo3Antonio Valle-Medina4Osvaldo Garrido-Acosta5Alfredo Ramirez6Unidad de Investigación Epidemiológica y en Servicios de Salud, Área Envejecimiento, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, MexicoEpidemiology, Endocrinology, and Nutrition Research Unit, Hospital Infantil de México Federico Gomez, Ministry of Health (SSA), Mexico City, MexicoDepartment of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, MexicoDepartment of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, MexicoSección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City, MexicoFacultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, Mexico City, MexicoDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Köln, GermanyObjectiveEvidence supports the important role of neuroinflammation in some types of dementia. This study aimed to evaluate the effect of epistasis of gene cytokines such as interleukin (IL)-α, IL-6, tumor necrosis factor (TNFα), and interferon-gamma (IFN-γ) on the susceptibility to the development of dementia.Materials and methodsIn the study, 221 patients diagnosed with dementia and 710 controls were included. The multifactor-dimensionality reduction (MDR) analysis was performed to identify the epistasis between SNP located in genes of IL-α (rs1800587), IL-6 (rs1800796), TNFα (rs361525 and rs1800629), and IFNγ (rs2069705). The best risk prediction model was identified based on precision and cross-validation consistency.ResultsMultifactor-dimensionality reduction analysis detected a significant model with the genes TNFα, IFNγ, IL1α, and IL6 (prediction success: 72%, p < 0.0001). When risk factors were analyzed with these polymorphisms, the model achieved a similar prediction for dementia as the genes-only model.ConclusionThese data indicate that gene–gene interactions form significant models to identify populations susceptible to dementia.https://www.frontiersin.org/articles/10.3389/fnagi.2022.952173/fullpolymorphismcytokine genesdementiaMDRgene–gene interaction |
| spellingShingle | Teresa Juárez-Cedillo Nancy Martínez-Rodríguez Gilberto Vargas-Alarcon Enrique Juárez-Cedillo Antonio Valle-Medina Osvaldo Garrido-Acosta Alfredo Ramirez Synergistic influence of cytokine gene polymorphisms over the risk of dementia: A multifactor dimensionality reduction analysis Frontiers in Aging Neuroscience polymorphism cytokine genes dementia MDR gene–gene interaction |
| title | Synergistic influence of cytokine gene polymorphisms over the risk of dementia: A multifactor dimensionality reduction analysis |
| title_full | Synergistic influence of cytokine gene polymorphisms over the risk of dementia: A multifactor dimensionality reduction analysis |
| title_fullStr | Synergistic influence of cytokine gene polymorphisms over the risk of dementia: A multifactor dimensionality reduction analysis |
| title_full_unstemmed | Synergistic influence of cytokine gene polymorphisms over the risk of dementia: A multifactor dimensionality reduction analysis |
| title_short | Synergistic influence of cytokine gene polymorphisms over the risk of dementia: A multifactor dimensionality reduction analysis |
| title_sort | synergistic influence of cytokine gene polymorphisms over the risk of dementia a multifactor dimensionality reduction analysis |
| topic | polymorphism cytokine genes dementia MDR gene–gene interaction |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.952173/full |
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