High hedgehog signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR smoothened

High hedgehog signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR smoothened

The oncogenic G-protein-coupled receptor (GPCR) Smoothened (SMO) is a key transducer of the hedgehog (HH) morphogen, which plays an essential role in the patterning of epithelial structures. Here, we examine how HH controls SMO subcellular localization and activity in a polarized epithelium using th...

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Autori principali: Marina Gonçalves Antunes, Matthieu Sanial, Vincent Contremoulins, Sandra Carvalho, Anne Plessis, Isabelle Becam
Natura: Articolo
Lingua:English
Pubblicazione: eLife Sciences Publications Ltd 2022-09-01
Serie:eLife
Soggetti:
hedgehog
smoothened
Drosophila
apico-basal polarity
protein trafficking
phosphorylation
Accesso online:https://elifesciences.org/articles/79843

Accesso online

https://elifesciences.org/articles/79843

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