In vitro/in vivo evaluation of statistically engineered alginate scaffold reinforced with dual drugs loaded silica nanoparticles for enhanced fungal therapeutics

In vitro/in vivo evaluation of statistically engineered alginate scaffold reinforced with dual drugs loaded silica nanoparticles for enhanced fungal therapeutics

In the current study, sustained release salicylic acid (SA) and ketoconazole (KCZ) loaded silica nanoparticles (SiO2-NPs) were encapsulated in natural macromolecule-alginate (ALG) based scaffold through freeze gelation method for an effective treatment of commonly prevailed fatal fungal infections....

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Bibliographic Details
Main Authors: Syeda Amna Masood, Safirah Maheen, Hafeez Ullah Khan, Muhammad Nadeem Zafar, Syed Salman Shafqat, M.A. Mujtaba, Atta ur Rehman, Ghulam Abbas, Mian H.R. Mahmood, Shahid Bashir, T.M. Yunus Khan, Amany Salah Khalifa
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:Alexandria Engineering Journal
Subjects:
Alginate
Central composite design
Fungal therapeutics
Ketoconazole
Salicylic acid
Silica nanoparticles
Online Access:http://www.sciencedirect.com/science/article/pii/S1110016821006293

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http://www.sciencedirect.com/science/article/pii/S1110016821006293

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