Lanosterol synthase deficiency promotes tumor progression by orchestrating PDL1‐dependent tumor immunosuppressive microenvironment

Lanosterol synthase deficiency promotes tumor progression by orchestrating PDL1‐dependent tumor immunosuppressive microenvironment

Abstract Lipid metabolic reprogramming is closely related to tumor progression with the mechanism not fully elucidated. Here, we report the immune‐regulated role of lanosterol synthase (LSS), an essential enzyme in cholesterol synthesis. Database analysis and clinical sample experiments suggest that...

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Bibliographic Details
Main Authors: Yuan Gao, Kun Zhao, Yulan Huang, Dapeng Zhang, Na Luo, Xiaoqing Peng, Feng Yang, Weidong Xiao, Meng Wang, Rongchen Shi, Hongming Miao
Format: Article
Language:English
Published: Wiley 2024-04-01
Series:MedComm
Subjects:
lanosterol synthase
programmed cell death ligand 1
tumor immunity
tumor microenvironment
Online Access:https://doi.org/10.1002/mco2.528

Internet

https://doi.org/10.1002/mco2.528

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