Residues 315 and 369 in HN Protein Contribute to the Thermostability of Newcastle Disease Virus

Residues 315 and 369 in HN Protein Contribute to the Thermostability of Newcastle Disease Virus

Thermostable Newcastle disease virus (NDV) vaccines have been widely used in areas where a “cold-chain” is not reliable. However, the molecular mechanism of NDV thermostability remains poorly understood. In this work, we constructed chimeric viruses by exchanging viral fusion (F) and/or hemagglutini...

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Bibliographic Details
Main Authors: Baoyang Ruan, Xiaorong Zhang, Chengcheng Zhang, Pengyu Du, Chengcheng Meng, Mengjiao Guo, Yantao Wu, Yongzhong Cao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Microbiology
Subjects:
Newcastle disease
thermostability
HN gene
mutations
chimeric viruses
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.560482/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.560482/full

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