An experimental and theoretical aided 2D MoS2 nanoflowers strategy for rapid visual sensing of Gallic acid in food and clinical matrixes
Gallic acid (GA), an important phenolic component, is gaining popularity due to its biological and industrial applications. However, its rapid expansion can be hazardous, causing cancer and gene damage, making the design of a low-cost and fast GA sensor difficult. We used a single-step hydrothermal...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Applied Surface Science Advances |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666523924000096 |
| _version_ | 1797253923244867584 |
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| author | Aizaz Khan Huma Ajab Asim Yaqub Khurshid Ayub Muhammad Yar Habib Ullah |
| author_facet | Aizaz Khan Huma Ajab Asim Yaqub Khurshid Ayub Muhammad Yar Habib Ullah |
| author_sort | Aizaz Khan |
| collection | DOAJ |
| description | Gallic acid (GA), an important phenolic component, is gaining popularity due to its biological and industrial applications. However, its rapid expansion can be hazardous, causing cancer and gene damage, making the design of a low-cost and fast GA sensor difficult. We used a single-step hydrothermal approach to synthesize MoS2 nanoparticles for colorimetric detection of GA. The nanoparticles were analyzed using techniques like; UV–Vis spectroscopy, FT-IR spectroscopy, SEM, EDX and XRD. The optimization of key parameters such as MoS2 concentration (2.0 mg), temperature (30 °C), and pH (7) resulted in a limit of detection (LOD) of 0.125 × 10−6 M with a dynamic range of 0.5 to 36 × 10−6 M. MoS2 nanoflowers performed as nanozymes in the filter paper-based sensor, catalyzing 3, 3′, 5, 5′-tetramethylbenzidine (TMB) oxidation, while GA acted as an inhibitor to prevent further reaction progression. The detection was made feasible through capturing an image support by an ordinary smartphone and the steady-state kinetic study validated MoS2 nanoflowers' affinity for sensing H2O2. The sensor performed well in real-world samples such as diet tea, green tea, water, blood serum, and urine, with recovery rates ranging from 93.2 % to 102.1 %. Density functional theory calculations were applied to provide an insight into GA-MoS2 binding interactions and changes in electronic properties. With all of these merits, we believe MoS2 nanoparticles can provide low-cost and portable filter paper-based strips as a sensing platform for visual assessment of GA. |
| first_indexed | 2024-03-07T21:52:35Z |
| format | Article |
| id | doaj.art-a648eee85f1f49239b802792e048264c |
| institution | Directory Open Access Journal |
| issn | 2666-5239 |
| language | English |
| last_indexed | 2024-04-24T21:41:46Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Applied Surface Science Advances |
| spelling | doaj.art-a648eee85f1f49239b802792e048264c2024-03-21T05:37:44ZengElsevierApplied Surface Science Advances2666-52392024-04-0120100581An experimental and theoretical aided 2D MoS2 nanoflowers strategy for rapid visual sensing of Gallic acid in food and clinical matrixesAizaz Khan0Huma Ajab1Asim Yaqub2Khurshid Ayub3Muhammad Yar4Habib Ullah5Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, PakistanDepartment of Chemistry, COMSATS University Islamabad, Abbottabad Campus, Pakistan; Corresponding author.Department of Environmental Sciences, COMSATS University Islamabad, Abbottabad Campus, PakistanDepartment of Chemistry, COMSATS University Islamabad, Abbottabad Campus, PakistanDepartment of Chemistry, COMSATS University Islamabad, Abbottabad Campus, PakistanCollege of Engineering, Mathematics and Physical Sciences, University of Exeter, Penryn Campus, Cornwall TR10 9FE, United KingdomGallic acid (GA), an important phenolic component, is gaining popularity due to its biological and industrial applications. However, its rapid expansion can be hazardous, causing cancer and gene damage, making the design of a low-cost and fast GA sensor difficult. We used a single-step hydrothermal approach to synthesize MoS2 nanoparticles for colorimetric detection of GA. The nanoparticles were analyzed using techniques like; UV–Vis spectroscopy, FT-IR spectroscopy, SEM, EDX and XRD. The optimization of key parameters such as MoS2 concentration (2.0 mg), temperature (30 °C), and pH (7) resulted in a limit of detection (LOD) of 0.125 × 10−6 M with a dynamic range of 0.5 to 36 × 10−6 M. MoS2 nanoflowers performed as nanozymes in the filter paper-based sensor, catalyzing 3, 3′, 5, 5′-tetramethylbenzidine (TMB) oxidation, while GA acted as an inhibitor to prevent further reaction progression. The detection was made feasible through capturing an image support by an ordinary smartphone and the steady-state kinetic study validated MoS2 nanoflowers' affinity for sensing H2O2. The sensor performed well in real-world samples such as diet tea, green tea, water, blood serum, and urine, with recovery rates ranging from 93.2 % to 102.1 %. Density functional theory calculations were applied to provide an insight into GA-MoS2 binding interactions and changes in electronic properties. With all of these merits, we believe MoS2 nanoparticles can provide low-cost and portable filter paper-based strips as a sensing platform for visual assessment of GA.http://www.sciencedirect.com/science/article/pii/S2666523924000096SensorColorimetricGallic acidFoodEnvironmentDFT |
| spellingShingle | Aizaz Khan Huma Ajab Asim Yaqub Khurshid Ayub Muhammad Yar Habib Ullah An experimental and theoretical aided 2D MoS2 nanoflowers strategy for rapid visual sensing of Gallic acid in food and clinical matrixes Applied Surface Science Advances Sensor Colorimetric Gallic acid Food Environment DFT |
| title | An experimental and theoretical aided 2D MoS2 nanoflowers strategy for rapid visual sensing of Gallic acid in food and clinical matrixes |
| title_full | An experimental and theoretical aided 2D MoS2 nanoflowers strategy for rapid visual sensing of Gallic acid in food and clinical matrixes |
| title_fullStr | An experimental and theoretical aided 2D MoS2 nanoflowers strategy for rapid visual sensing of Gallic acid in food and clinical matrixes |
| title_full_unstemmed | An experimental and theoretical aided 2D MoS2 nanoflowers strategy for rapid visual sensing of Gallic acid in food and clinical matrixes |
| title_short | An experimental and theoretical aided 2D MoS2 nanoflowers strategy for rapid visual sensing of Gallic acid in food and clinical matrixes |
| title_sort | experimental and theoretical aided 2d mos2 nanoflowers strategy for rapid visual sensing of gallic acid in food and clinical matrixes |
| topic | Sensor Colorimetric Gallic acid Food Environment DFT |
| url | http://www.sciencedirect.com/science/article/pii/S2666523924000096 |
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