Defibrotide Prophylaxis of Sinusoidal Obstruction Syndrome in Adults Treated With Inotuzumab Ozogamicin Prior to Hematopoietic Stem Cell Transplantation

Defibrotide Prophylaxis of Sinusoidal Obstruction Syndrome in Adults Treated With Inotuzumab Ozogamicin Prior to Hematopoietic Stem Cell Transplantation

Sinusoidal Obstruction Syndrome (SOS) is a life threatening HSCT complication and it can rapidly evolve in Multiple Organ Dysfunction Syndrome, with a mortality exceeding 80%. Early treatment with defibrotide is the leading factor for efficacy. Its prophylactic use is recommended in the pediatric se...

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Bibliographic Details
Main Authors: Fabio Giglio, Elisabetta Xue, Raffaella Greco, Lorenzo Lazzari, Daniela Teresa Clerici, Francesca Lorentino, Sara Mastaglio, Sarah Marktel, Maria Teresa Lupo-Stanghellini, Magda Marcatti, Consuelo Corti, Massimo Bernardi, Simona Piemontese, Fabio Ciceri, Jacopo Peccatori
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Oncology
Subjects:
Inotuzumab ozogamicin
defibrotide
prophylaxis
SOS
VOD
Allo-HCT
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.933317/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.933317/full

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