Conformational Ensembles Explored Dynamically from Disordered Peptides Targeting Chemokine Receptor CXCR4

Conformational Ensembles Explored Dynamically from Disordered Peptides Targeting Chemokine Receptor CXCR4

This work reports on the design and the synthesis of two short linear peptides both containing a few amino acids with disorder propensity and an allylic ester group at the C-terminal end. Their structural properties were firstly analyzed by means of experimental techniques in solution such as CD and...

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Bibliographic Details
Main Authors: Marian Vincenzi, Susan Costantini, Stefania Scala, Diego Tesauro, Antonella Accardo, Marilisa Leone, Giovanni Colonna, Jean Guillon, Luigi Portella, Anna Maria Trotta, Luisa Ronga, Filomena Rossi
Format: Article
Language:English
Published: MDPI AG 2015-05-01
Series:International Journal of Molecular Sciences
Subjects:
intrinsically disordered protein (IDP)
intrinsically disordered region (IDR)
conformational ensemble
MD
NMR
CD
chemokine
Online Access:http://www.mdpi.com/1422-0067/16/6/12159

Internet

http://www.mdpi.com/1422-0067/16/6/12159

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