Leverage of nuclease-deficient CasX for preventing pathological angiogenesis

Leverage of nuclease-deficient CasX for preventing pathological angiogenesis

Gene editing with a CRISPR/Cas system is a novel potential strategy for treating human diseases. Pharmacological inhibition of phosphoinositide 3-kinase (PI3K) δ suppresses retinal angiogenesis in a mouse model of oxygen-induced retinopathy. Here we show that an innovative system of adeno-associated...

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Bibliographic Details
Main Authors: Haote Han, Yanhui Yang, Yunjuan Jiao, Hui Qi, Zhuo Han, Luping Wang, Lijun Dong, Jingkui Tian, Bart Vanhaesebroeck, Xiaopeng Li, Junwen Liu, Gaoen Ma, Hetian Lei
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: RNA/DNA editing
CRISPR/dCasX-KRAB
rAAV1
Pik3cd
PI3Kδ
oxygen-induced retinopathy
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253123002135

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http://www.sciencedirect.com/science/article/pii/S2162253123002135

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