Macrophages-derived Factor XIII links coagulation to inflammation in COPD
BackgroundThe local, extravascular, activation of the coagulation system in response to injury is a key factor mediating the resulting inflammatory response. Coagulation Factor XIIIA (FXIIIA) found in alveolar macrophages (AM) and dendritic cells (DC), by influencing fibrin stability, might be an in...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1131292/full |
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| author | Erica Bazzan Alvise Casara Claudia Maria Radu Mariaenrica Tinè Davide Biondini Davide Biondini Eleonora Faccioli Federica Pezzuto Nicol Bernardinello Maria Conti Elisabetta Balestro Fiorella Calabrese Paolo Simioni Federico Rea Graziella Turato Paolo Spagnolo Manuel G. Cosio Manuel G. Cosio Marina Saetta |
| author_facet | Erica Bazzan Alvise Casara Claudia Maria Radu Mariaenrica Tinè Davide Biondini Davide Biondini Eleonora Faccioli Federica Pezzuto Nicol Bernardinello Maria Conti Elisabetta Balestro Fiorella Calabrese Paolo Simioni Federico Rea Graziella Turato Paolo Spagnolo Manuel G. Cosio Manuel G. Cosio Marina Saetta |
| author_sort | Erica Bazzan |
| collection | DOAJ |
| description | BackgroundThe local, extravascular, activation of the coagulation system in response to injury is a key factor mediating the resulting inflammatory response. Coagulation Factor XIIIA (FXIIIA) found in alveolar macrophages (AM) and dendritic cells (DC), by influencing fibrin stability, might be an inflammatory modifier in COPD.AimsTo study the expression of FXIIIA in AM and Langerin+DC (DC-1) and their relation to the inflammatory response and disease progression in COPD.MethodsIn 47 surgical lungs, 36 from smokers (22 COPD and 14 no-COPD) and 11 from non-smokers we quantified by immunohistochemistry FXIIIA expression in AM and DC-1 along with numbers of CD8+Tcells and CXCR3 expression in lung parenchyma and airways. Lung function was measured prior to surgery.ResultsThe percentage of AM expressing FXIII (%FXIII+AM) was higher in COPD than no-COPD and non-smokers. DC-1 expressed FXIIIA and their numbers were higher in COPD than no-COPD and non-smokers. DC-1 positively correlated with %FXIII+AM (r=0.43; p<0.018). CD8+Tcells, which were higher in COPD than in no-COPD, were correlated with DC-1 (p<0.01) and %FXIII+AM. CXCR3+ cells were increased in COPD and correlated with %FXIII+AM (p<0.05). Both %FXIII+AM (r=-0.6; p=0.001) and DC-1 (r=-0.7; p=0.001) correlated inversely with FEV1.ConclusionFXIIIA, an important link between the extravascular coagulation cascade and inflammatory response, is significantly expressed in alveolar macrophages and dendritic cells of smokers with COPD, suggesting that it could play an important role in the adaptive inflammatory reaction characteristic of the disease. |
| first_indexed | 2024-04-09T16:07:48Z |
| format | Article |
| id | doaj.art-a65674a5780542998efca4fbf8209111 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-09T16:07:48Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-a65674a5780542998efca4fbf82091112023-04-25T04:42:20ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-04-011410.3389/fimmu.2023.11312921131292Macrophages-derived Factor XIII links coagulation to inflammation in COPDErica Bazzan0Alvise Casara1Claudia Maria Radu2Mariaenrica Tinè3Davide Biondini4Davide Biondini5Eleonora Faccioli6Federica Pezzuto7Nicol Bernardinello8Maria Conti9Elisabetta Balestro10Fiorella Calabrese11Paolo Simioni12Federico Rea13Graziella Turato14Paolo Spagnolo15Manuel G. Cosio16Manuel G. Cosio17Marina Saetta18Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, ItalyDepartment of Medicine, University of Padova, Padova, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, ItalyDepartment of Medicine, University of Padova, Padova, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, ItalyDepartment of Medicine, University of Padova, Padova, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, ItalyMeakins-Christie Laboratories, Respiratory Division, McGill University, Montreal, QC, CanadaDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, ItalyBackgroundThe local, extravascular, activation of the coagulation system in response to injury is a key factor mediating the resulting inflammatory response. Coagulation Factor XIIIA (FXIIIA) found in alveolar macrophages (AM) and dendritic cells (DC), by influencing fibrin stability, might be an inflammatory modifier in COPD.AimsTo study the expression of FXIIIA in AM and Langerin+DC (DC-1) and their relation to the inflammatory response and disease progression in COPD.MethodsIn 47 surgical lungs, 36 from smokers (22 COPD and 14 no-COPD) and 11 from non-smokers we quantified by immunohistochemistry FXIIIA expression in AM and DC-1 along with numbers of CD8+Tcells and CXCR3 expression in lung parenchyma and airways. Lung function was measured prior to surgery.ResultsThe percentage of AM expressing FXIII (%FXIII+AM) was higher in COPD than no-COPD and non-smokers. DC-1 expressed FXIIIA and their numbers were higher in COPD than no-COPD and non-smokers. DC-1 positively correlated with %FXIII+AM (r=0.43; p<0.018). CD8+Tcells, which were higher in COPD than in no-COPD, were correlated with DC-1 (p<0.01) and %FXIII+AM. CXCR3+ cells were increased in COPD and correlated with %FXIII+AM (p<0.05). Both %FXIII+AM (r=-0.6; p=0.001) and DC-1 (r=-0.7; p=0.001) correlated inversely with FEV1.ConclusionFXIIIA, an important link between the extravascular coagulation cascade and inflammatory response, is significantly expressed in alveolar macrophages and dendritic cells of smokers with COPD, suggesting that it could play an important role in the adaptive inflammatory reaction characteristic of the disease.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1131292/fullCOPD - chronic obstructive pulmonary diseasemacrophagecoagulationinflammationinjury |
| spellingShingle | Erica Bazzan Alvise Casara Claudia Maria Radu Mariaenrica Tinè Davide Biondini Davide Biondini Eleonora Faccioli Federica Pezzuto Nicol Bernardinello Maria Conti Elisabetta Balestro Fiorella Calabrese Paolo Simioni Federico Rea Graziella Turato Paolo Spagnolo Manuel G. Cosio Manuel G. Cosio Marina Saetta Macrophages-derived Factor XIII links coagulation to inflammation in COPD Frontiers in Immunology COPD - chronic obstructive pulmonary disease macrophage coagulation inflammation injury |
| title | Macrophages-derived Factor XIII links coagulation to inflammation in COPD |
| title_full | Macrophages-derived Factor XIII links coagulation to inflammation in COPD |
| title_fullStr | Macrophages-derived Factor XIII links coagulation to inflammation in COPD |
| title_full_unstemmed | Macrophages-derived Factor XIII links coagulation to inflammation in COPD |
| title_short | Macrophages-derived Factor XIII links coagulation to inflammation in COPD |
| title_sort | macrophages derived factor xiii links coagulation to inflammation in copd |
| topic | COPD - chronic obstructive pulmonary disease macrophage coagulation inflammation injury |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1131292/full |
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